Anti-oxidant and anti-inflammatory cyclic diarylheptanoids from Alnus japonica stem bark

A new cyclic diarylheptanoid namely alnuheptanoid b (3),along with four known cyclic diarylheptanoids: myricanone (1),(+)-s-myricanol (2),myricanone 5-o-β-d-glucopyranoside (4),and (+)-s-myricanol 5-o-β-d-glucopyranoside (5) were isolated from the etoac fraction of alnus japonica steud (family: betulaceae) stem bark. their structures were established by different spectroscopic analyses,as well as optical rotation measurement. compounds 1,2,4,and 5 are isolated for the first time from a. japonica. the antioxidant and anti-inflammatory activities of compounds (1-5) were assessed using dpph assay and carrageenin induced rat paw edema model,respectively. they displayed significant antioxidant activity in relation to propyl gallate (standard antioxidant) at concentration 50 µm. compound 2 demonstrated anti-inflammatory effect at a dose 10 mg/kg compared with indomethacin (positive control). © 2017 by school of pharmacy.