Preparation and optimization OF palm-based lipid nanoparticles loaded with griseofulvin

Palm-based lipid nanoparticle formulation loaded with griseofulvin was prepared by solvent-free hot homogenization method. the griseofulvin loaded lipid nanoparticles were prepared via stages of optimisation,by altering the high pressure homogenisation (hph) parameters,screening on palm-based lipids and tween series surfactants and selection of lipid to surfactant ratios. a hplc method has been validated for the drug loading capacity study. the optimum hph parameter was determined to be 1500 bar with 5 cycles and among the palm-based lipid materials; lipid c (triglycerides) was selected for the preparation of lipid nanoparticles. tween 80 was chosen from the tween series surfactants for its highest saturated solubility of griseofulvin at 53.1 ± 2.16 µg/ml. the optimum formulation of the griseofulvin loaded lipid nanoparticles demonstrated nano-range of particle size (179.8 nm) with intermediate distribution index (pdi) of 0.306,zeta potential of -27.9 mv and drug loading of 0.77%. the formulation was stable upon storage for 1 month at room temperature (25°c) and 45°c with consistent drug loading capacity. © 2017 by school of pharmacy.