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Microbial hydroxylation of 16α,17α-epoxyprogesterone by Penicillium Decumbens
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نویسنده
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mao s. ,wang x. ,ge z. ,su a. ,zhang l. ,li y. ,liu x. ,lu f.
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منبع
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iranian journal of pharmaceutical research - 2017 - دوره : 16 - شماره : 3 - صفحه:1163 -1168
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چکیده
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Microbial transformation has been successfully applied in the production of steroid intermediates with therapeutic use and commercial value in pharmaceutical industry due to its high regio- and stereo-selectivity. as such,it is still important to screen microbial strains with novel activity or more efficient abilities in the development of the commercial steroid industry. biotransformation of steroid: 16α,17α-epoxyprogesterone (1). using penicilliumdecumbens as biocatalyst was investigated and selective hydroxylation of 1 was observed. the products were separated by silica gel column chromatography,and the structure determination was performed by ms,nmr,and x-ray crystallography. biotransformation of 1 afforded 7β-hydroxy-16α,17α-epoxyprogesterone (2). and 7β,11α-dihydroxy-16α,17α- epoxyprogesterone (3). the two novel metabolic products 2 and 3 were reported for the first time. moreover,the identified c7β- and c11-αhydroxylation is a novel reaction of microbial transformation of steroids by p.decumbens. © 2017 by school of pharmacy shaheed beheshti university of medical sciences and health services.
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کلیدواژه
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16α; 17α-Epoxyprogesterone; Biotransformation; Hydroxylation; Penicillium decumbens; Steroid
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آدرس
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key laboratory of industrial fermentation microbiology,ministry of education,tianjin university of science & technology,tianjin, China, tianjin key laboratory of industrial microbiology,college of biotechnology,tianjin university of science & technology,tianjin, China, tianjin key laboratory of industrial microbiology,college of biotechnology,tianjin university of science & technology,tianjin, China, department of chemistry and chemical biology,rensselaer polytechnic institute,troy,ny, United States, tianjin key laboratory of industrial microbiology,college of biotechnology,tianjin university of science & technology,tianjin, China, tianjin key laboratory of industrial microbiology,college of biotechnology,tianjin university of science & technology,tianjin, China, key laboratory of industrial fermentation microbiology,ministry of education,tianjin university of science & technology,tianjin, China, key laboratory of industrial fermentation microbiology,ministry of education,tianjin university of science & technology,tianjin,china,tianjin key laboratory of industrial microbiology,college of biotechnology,tianjin university of science & technology,tianjin, China
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Authors
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