Sinapic acid derivatives as potential anti-inflammatory agents: Synthesis and biological evaluation

Transcription factor nf-κb and relevant cytokines il-6 and il-8 play a pivotal role in the pathogenesis of inflammation. sinapic acid is a natural product and was demonstrated to possess anti-inflammatory activity. in this paper,we synthesized a series of sinapic acid derivatives and evaluated their anti-inflammatory effects. the result suggested that all of the targets compounds 7a-j inhibit nf-κb activation and decrease il-6 and il-8 expression in beas-2b cells. by our biological assays,we found that all of the prepared compounds displayed stronger anti-inflammatory activities than their precursor sinapic acid. especially,compounds 7g and 7i,with electron-drawing groups (nitro and fluoro moieties) in the benzimidazole ring,exhibited remarkable anti-inflammation activity,which was even stronger than the reference drug dexamethasone. © 2017 by school of pharmacy shaheed beheshti university of medical sciences and health services.