Adsorptive behavior and voltammetric determination of hydralazine hydrochloride at a glassy carbon electrode modified with multiwalled carbon nanotubes

An electroanalytical method has been introduced for highly sensitive determination of hydralazine hydrochloride (hy-hcl) based on its oxidation at a glassy carbon electrode modified with multiwalled carbon nanotubes (mwcnt/gce). studies showed that the electrochemical oxidation of hy-hcl was accompanied by adsorption and highly sensitive responses could be achieved by adsorptive stripping voltammetry. the electrooxidation of hy-hcl at mwcnt/ gce occurred at ~32 mv which was lower than that observed at bare gce (~52 mv). the optimum working conditions for determination of the drug using differential-pulse adsorptive stripping voltammetry (dpadsv) were established. the method exhibited linear responses to hy-hcl in the concentration range 10-220 nm with a detection limit of 2.7 nm. the proposed method was successfully applied to the determination of this compound in pharmaceutical dosage forms. © 2017 by school of pharmacy shaheed beheshti university of medical sciences and health services.