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Antihypertensive effects of some new nitroxyalkyl 1,4-dihydropyridine derivatives in rat model of two-kidney, one-clip hypertension
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نویسنده
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Nekooeian Ali Akbar ,Khalili Azadeh ,Javidnia Katayoun ,Mehdipour Ahmad Reza ,Miri Ramin
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منبع
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iranian journal of pharmaceutical research - 2009 - دوره : 8 - شماره : 3 - صفحه:193 -199
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چکیده
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Dihydropyridine calcium channel blockers consist one of the widely-used groups of drugs for the management of hypertension. in this study, antihypertensive effects of 5 newly synthesized derivatives of dhp was examined the in rat model of two-kidney, one-clip renal hypertension. the results showed that those compounds containing two nitroxy groups had less decreasing effect on map (men arterial pressure) compared to those having one nitroxy group in 5 position. on the other hand, conformational analysis indicated that in two compounds with two chains (a and e), a great steric hindrance existed; therefore, steric hindrance is the most important factor for interaction of compounds with their receptors.
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کلیدواژه
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two-kidney; one-clip hypertension; 1 ,4-dihydropyridines; MAP.
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آدرس
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shiraz university of medical sciences, Faculty of Medicine, Department of Pharmacology, ایران, shiraz university of medical sciences, Faculty of Medicine, Department of Pharmacology, ایران, shiraz university of medical sciences, Medicinal & Natural Products Chemistry Research Centre,Faculty of Pharmacy, Department of Medicinal Chemistry, ایران, shiraz university of medical sciences, Medicinal & Natural Products Chemistry Research Centre, ایران, shiraz university of medical sciences, Medicinal & Natural Products Chemistry Research Centre,Faculty of Pharmacy, Department of Medicinal Chemistry, ایران
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پست الکترونیکی
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mirir@sums.ac.ir
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Authors
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