No Significant Difference Between Intact and Testosterone Depleted or Administrated Male Rats in Spatial Learning and Memory

Androgens have been shown to affect cognitive aspects of spatial memory. testosteronewhich is the most important androgen, plays a role in the organization of behavior duringdevelopment. also, it has been shown that androgens cause sex related differences in learningand memory especially during neonatal period. in the current study, we assessed the effectsof castration and testosterone enanthate (te) administration on spatial cognition. multipledoses of testosterone enanthate (20, 40,80 and 120 mg/kg) were examined on different groupsusing morris water maze. spatial memory was preserved in castrated rats. there was also nodifference among multiple doses and control groups. for control of the level of testosterone inthe blood of casterated rats and intact rats, blood samples were collected from intact group and7,10,12,14,21 days after casteration. testosterone levels were measured by radio-immunoassay (ria) technique and compared among all groups. the level of testosterone after 7 daysin casterated rats were 0 nmol/l and after 21 days were 0.02(plus-minus)0.02 nmol/l while in intact ratswere 2.69±0.88 nmol/l. these data suggests that changes in the level of androgen in circulationhave no effect on spatial localization, at least after puberty in male rats