Synthesis and Antimicrobial Evaluation of New (4-Oxo-thiazolidinyl)quinazolin-4(3H)ones of 2-[(2,6-Dichlorophenyl)amino]phenylacetic acid

Synthesis of 2-[2-(2,6-dichlorophenyl)amino]phenylmethyl-3-[4-(2-substitutedphenyl-4-oxo-thiazolidinyl)aryl]-6-bromo quinazolin-4(3h)ones via-j have been achieved from the starting material 2-[(2,6-dichlorophenyl)amino] phenylacetic acid i to benzoxazine iii, further reaction with p-phenylindiamine and substituted aromatic aldehyde gave 2-[2-(2,6-dichlorophenyl)amino]phenyl methyl-3-(4-aminoaryl)-6-bromo quinazolin-4(3h)-ones iv and 2-[2-(2,6-dichlorophenyl)amino]phenylmethyl-3-[4-(2-substituted arylidene)aryl]-6-bromo quinazolin-4(3h)ones va-j respectively. v a-j on cyclization with thioglycolic acid gave v a-j. all the synthesized compounds have been characterized on the basis of elemental analysis, ir and 1h-nmr spectral data. they were screened for antibacterial and antifungal activity at two concentrations and compared with the standard drugs penicillin-g, ampicillin, and amoxicillin. the compounds containing 4-och3 and 3, 4, 5-(och3)3 showed good activity, compared with the standard drugs.