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The Involvement of L-Type Voltage-Operated Calcium Channels in the Vascular Effect of Quercetin in Male Rats
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نویسنده
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ROGHANI MEHRDAD ,BALUCHNEJADMOJARAD TOURANDOKHT ,ROGHANI DEHKORDI FARSHAD
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منبع
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iranian journal of pharmaceutical research - 2006 - دوره : 5 - شماره : 3 - صفحه:199 -202
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چکیده
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In this study, the possible involvement of l-type voltage-operated calcium channels inthe vasorelaxant effect of the flavonoid quercetin was investigated, using the isolated aorticrings from normal male rats. addition of quercetin (0.1 flm-1 mm) caused a significantdose-dependent relaxation of noradrenaline (na)- and kci-preconstricted rings andnifedipine attenuated this response, especially for noradrenaline (p(less than00.05). it is concludedthat the flavonoid quercetin produces a potent relaxation of the rat aorta and blockade ofvoltage-operated calcium channels could attenuate this effect.
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کلیدواژه
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Quercetin; Aorta; Calcium channel; Rat
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آدرس
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shahed university, School of Medicine, Department of Physiology, ایران, iran university of medical sciences, School of Medicine, Department of Physiology, ایران, shahrekord university of medical sciences, School of Medicine, Department of Cardiology and Internal Medicine, ایران
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پست الکترونیکی
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mehjour@yahoo.com
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Authors
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