Synthesis and Determination of Partition Coefficients of Zinc Complexes with Clinical Potential application

Zinc sulphate is currently used for treatment ofzinc deficiency. its uptake by the body is poor,necessitating the administration of high doses. this leads to a range of unpleasant side effects.in order to increase the bioavailability of zinc, several zinc complexes have been designedand synthesized using bidentate ligands of hydroxypyranones and hydroxypyridinones.elemental analysis in each zinc complex was consistent with the formulations of znl2 speciesl: bidentate ligand) with 1.5 or 7 water molecules per zinc and the water molecules wereremoved by heating in a vacuum oven to yield anhydrous zinc complexes.the partition coefficients (~art)of the complexes were also determined in l-octanollbuffer (at ph 7.40) system by using shake-flask method. it was found that, the complexeswith hydroxypyranone ligands possess higher ~art values than those with hydroxypyidinoneligands. therefore, the comparison of the complexes highlights the hydroxypyranone zinccomplexes as the most promising candidates for using in zinc deficiency. since it wasanticipated that this type of complexes probably possesses suitable lipophilicity to facilitatetheir penetration into the gastrointestinal tract.