Synthesis and antimicrobial activity of some tetrahydro quinolone diones and pyrano[2,3-d]pyrimidine derivatives

There has been special interest in the chemistry of quinolone and pyrimidine derivatives due to their diverse biological activities such as anticonvulsant,anti-malarial agents,antibacterial,antiviral,cytostatic,antithelemintic,antigenotoxic,anti-cancer agents. these compounds are also used as targeting delayed-type hypersensivity and anti-convulsant agents. as a part of our research works in the synthesis of pyrimidine derivatives containing biological activities,a series of novel pyrano[2,3-d]pyrimidine derivatives 2 and tetrahydro quinolone dione derivatives 3 were synthesized via reaction of tetrahydrobenzo[b]pyrano derivatives 1 with different reagents in suitable yields. the characterization of these synthesized compounds was established by ir,1h nmr and 13c nmr spectroscopic data. furthermore,all compounds were subsequently evaluated for their in-vitro antibacterial activity against three bacteria: staphylococcus aureus (attc-25923),escherichia coli (attc-25922) and bacillus anthracic (attc-25924). © 2015 by school of pharmacy shaheed beheshti university of medical sciences and health services.