Design,synthesis and evaluation of Antitubercular activity of novel Dihydropyridine containing imidazolyl substituent

Recent studies have indicated that 1,4-dihydropyridine-3,5-dicarboxamide derivatives show significant anti-tubercular activity. in this research,new derivatives of 1,4-dihydropyridine were designed and synthesized using hantzsch condensation in which dicyclohexyl and different dicyclohexylcarbamoyl were substituted at c-3 and c-5 positions of the dhp ring. in addition,4 (5)-chloro-2-methyl-5 (4)-imidazolyl moiety was substituted at c-4 position of dhp. the structure of synthetized compounds were characterized by tlc,ir,elemental analysis and proton nmr. based on the in vitro screening data,all of the designed and synthetized compounds (3a-3g) showed a good ability to inhibit the mycobacterium tuberculosis growth in terms of mic. aromatic carboxamide containing compounds were more potent than cyclohexyl derivative and the most potent compound was 3a (4-nitrophenyl derivative). the experimental data are in agreement with our computational predictions in terms of partial atomic charge of carbonyl moieties at the c-3 and c-5 positions of dhp ring and partition coefficient of the molecules. © 2015 by school of pharmacy shaheed beheshti university of medical sciences and health services.