Solubility of Naproxen in Polyethylene glycol 200 + Water mixtures at various temperatures

The solubility of naproxen in binary mixtures of polyethylene glycol 200 (peg 200) + water at the temperature range from 298.0 k to 318.0 k were reported. the combinations of jouyban- acree model + van’t hoff and jouyban-acree model + partial solubility parameters were used to predict the solubility of naproxen in peg 200 + water mixtures at different temperatures. combination of jouyban-acree model with van’t hoff equation can be used to predict solubility in peg 200 + water with only four solubility data in mono-solvents. the obtained solubility calculation errors vary from ~ 17 % up to 35 % depend on the number of required input data. non-linear enthalpy-entropy compensation was found for naproxen in the investigated solvent system and the jouyban−acree model provides reasonably accurate mathematical descriptions of the thermodynamic data of naproxen in the investigated binary solvent systems. © 2015 by school of pharmacy shaheed beheshti university of medical sciences and health services.