In vitro Release Kinetics Study of Diltiazem Hydrochloride from Wax and Kollidon SR Based Matrix Tablets

Extended-release matrix tablets of diltiazem hydrochloride (dtz) were prepared usingwaxy materials alone or in combination with kollidon sr. matrix waxy materials werecamauba wax (cw), bees wax (bw), cetyl alcohol (ca) and glyceryl monostearate (gms).dissolution studies were carried out by using a six stations usp xxii type 1 apparatus. thein vitro drug release study was done in 1000 ml phosphate buffer of ph 6.8 for 12 h. initialburst release was observed in case ofwaxy granules. tablets prepared in combination ofwaxygranules and kollidon sr sustained the drug release for more than 12 h. addition of ludipressinstead of kollidon sr caused the drug release faster (for less than 12 h). fitting the in vitrodrug release data to korsmeyer equation indicates that diffusion along with erosion could bethe mechanism of drug release. significant differences were found among the drug releaseprofile from different polymeric matrices.