Hypoglycemic Activity of Casearia esculenta Roxb. in Normal and Diabetic Albino Rats

The hypoglycemic effect of ethanolic extract of casearia esculenta was investigated onalloxan induced diabetic rats. the blood glucose levels were measured at 0, 1,2 and 3 h afterthe treatment. the ethanolic extract of c. esculenta (250 mg/kg) reduced the blood glucose ofnormal rat from 85.50(plus-minus)1.22 to 64.67(plus-minus)3.27 mg/dl, 3 h after oral administration of the extract(p(less than)0.05). it also significantly lowered blood glucose level in alloxan induced diabetic ratfrom 331.67(plus-minus)4.90 to 130.33±6.53 mg/dl, 3 h after oral administration of the extract (p(less than)0.05).the antihyperglycemic activity of c. esculenta was compared with tolbutamide, an oralhypoglycemic agent.