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Synthesis and Antidepressant Activity of N-Substituted Imidazole-5 Carboxamides in Forced Swimming Test Model.
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نویسنده
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Hadizadeh Farzin ,Hosseinzadeh Hossein ,Motamed-Shariaty Vahideh-Sadat ,Seifi Mahmood ,Kazemi Shahab
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منبع
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iranian journal of pharmaceutical research - 2008 - دوره : 7 - شماره : 1 - صفحه:29 -33
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چکیده
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Moclobemide is a selective and reversible monoamine oxidase-a inhibitor, which is used as an antidepressant. three moclobemide analogues were synthesized by replacing moclobemide phenyl ring with substituted imidazoles. so, n-[(4-morpholinyl) ethyl)]-1-benzyl-2-(alkylthio)- 1 h-imidazole-5-carboxamides (7a-c) were synthesizedand studied for the antidepressant activity using forced swimming test in mice. analogues 7a-cwere found to be more potent than moclobemide. minimum effective doses for moclobemideand analogues 7a-c were found to be 20, 2.5, 1.25 and 2.5 mg/kg i.p. respectively.
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کلیدواژه
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Imidazolecarboxamides; MAOIs; Antidepressant; Forced swimming model.
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آدرس
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mashhad university of medical sciences, Pharmacy Faculty , ایران, mashhad university of medical sciences, Pharmacy Faculty , ایران, mashhad university of medical sciences, Biotechnology and Pharmaceutical Research Center , ایران, mashhad university of medical sciences, Biotechnology and Pharmaceutical Research Center , ایران, mashhad university of medical sciences, Biotechnology and Pharmaceutical Research Center , ایران
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پست الکترونیکی
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hadizadehf@mums.ac.ir
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Authors
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