Determination of Residual Methylmethacrylate Monomer in Denture Base Resins by Gas Chromatography

Acryli c base resins are widely used in orthopedics and dental surgery. it is generallyaccepted that due to the incomplete conversion of methyl methacrylate (mma) monomer tothe polymer form during polymerization of the resin, some mma monomers remain in thehardened material. mma monomer has been reported to cause abnormalities or lesion s inseveral organ s of animals. study of the literatures showed that there are no perfect and validmethods for analysis ofmma. the aim of this study was to develop a simple and valid methodfor determination of mma residual monomer in the denture base resins.we have developed and validated an analytical procedure employing gas chromatographywith flame ionization detector (gc-fid), with temperature programming, and a close analogueintemal standard for fast and repeatable analysis of mma residual monomer contents indenture base polymers. for quantification of monomer, two calibration curves were used bytwo diffe rent methods of solution preparation and they were compared to each other. theassay was linear over the range of 0.03-0 .6 mg/ml mma with correlation coefficients (r2) ofgreater than 0.99. accuracy, intra-day (error<9.1%) and inter-day (error<6.6%) , precision(rsd<5.5% and rsd<6.5%, respecti vely) were in acceptable values over the examinedconcentration range . limit of detection (lod) and limit of quantification (loq) for mmawere 0.0 i and 0.02 mg/ml , respectively. in conclusion, the propo sed method was a simple andfast assay for mma residual monomer in denture base resins. .