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Procerenone: a Fatty Acid Triterpenoid from the Fruit Pericarp of Omphalocarpum procerum (Sapotaceae)
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نویسنده
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Ngamgwe Rosine Fotsing ,Yankam Raoul ,Chouna Jean Rodolphe ,Lanz Christian ,Furrer Julien ,Schürch Stefan ,Kaiser Marcel ,Lenta Bruno Ndjakou ,Ngouela Silvère ,Tsamo Etienne ,Brenneisen Rudolf
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منبع
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iranian journal of pharmaceutical research - 2014 - دوره : 13 - شماره : 4 - صفحه:1425 -1430
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چکیده
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Phytochemical investigation of a dichloromethane-methanol (1:1) extract of the fruit pericarp of omphalocarpum procerum which exhibited antiplasmodial activity during preliminary screening led to the isolation of the new fatty ester triterpenoid 3β-hexadecanoyloxy-28- hydroxyolean-12-en-11-one (1), together with five known compounds 2-6. the structure of the new compound as well as those of the known compounds was established by means of spectroscopic methods and by comparison with previously reported data. compounds 1- 4 were evaluated in-vitro for their cytotoxicity against l6 cell lines and antiprotozoal activities against plasmodium falciparum, leishmania donovani, trypanosoma brucei rhodesiense and trypanosoma cruzi (species responsible for human malaria, visceral leishmaniasis, african trypanosomiasis and chagas disease, respectively). the tested compounds showed weak to moderate antiprotozoal activity and, no significant effect was detected regarding their cytotoxic potency.
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کلیدواژه
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Sapotaceae; Omphalocarpum procerum; Triterpenoid; Procerenone; Antiparasitic activity.
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آدرس
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University of Yaoundé, Faculty of Science, Department of Organic Chemistry, TWAS Research Unit, Cameroon, University of Bern, Department of Clinical Research, Switzerland, University of Dschang, Faculty of Science, Department of Chemistry, Cameroon, University of Bern, Department of Clinical Research, Switzerland, University of Bern, Department of Chemistryand Biochemistry, Switzerland, University of Bern, Department of Chemistryand Biochemistry, Switzerland, SwissTropical and Public Health Institute, Switzerland. University of Basel, Switzerland, University of Yaoundé, Higher TeacherTraining College, Department of Chemistry, Cameroon, University of Bern, Department of Clinical Research, Switzerland, University of Yaoundé, Faculty of Science, Department of Organic Chemistry, TWAS Research Unit, Cameroon, University of Bern, Department of Clinical Research, Switzerland
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Authors
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