Plasma Vitamin D Status and Its Correlation with Risk Factors of Thrombosis, P-selectin and hs-CRP Level in Patients with Venous Thromboembolism; the First Study of Iranian Population

Low plasma level of vitamin d is linked to the increased risk of cardiovascular diseases such as hypertension, diabetes, dyslipidemia and peripheral vascular diseases. vitamin d deficiency is a worldwide problem that involves iranian population. to the best of our knowledge, this was the first investigation on venous thromboembolism (vte) subjects that assessed the correlation of vitamin d level with plasma p-selectin, hs-crp, and risk factors of thrombosis. in this prospective pilot study, patients with diagnosis of acute deep vein thrombosis and/ or pulmonary embolism were enrolled. all patients’ clinical data, demographics and risk factors of thrombosis were evaluated. plasma level of p-selectin and hs-crp were measured by elisa method. radio immune assay method was used to determine plasma level of 25-hydroxy vitamin d (25(oh) d). in this study, 60 subjects were included. the mean ± sd plasma 25-hydroxy vitamin d level (25(oh) d) of participants was 21.4 ± 14.6 ng/ml. the vitamin d deficiency was detected in 60% of patients. no significant relation was found between the plasma 25(oh)d level and p-selectin and hs-crp. in multiple regression analysis, there was a significant relationship between the level of 25(oh)d and the patients’ age (beta = 0.452; p = 0.001), diabetes (beta = 0.280; p = 0.036) and positive family history of cardiovascular diseases (beta = 0.373; p = 0.003). vitamin d deficiency is a frequent problem in iranian vte patients. moreover, plasma level of vitamin d is not associated with p-selectin and hs-crp in vte patients.