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Sustained Release of Naproxen in a New Kind Delivery System of Carbon Nanotubes Hydrogel
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نویسنده
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Peng Xiahui ,Zhuang Qiang ,Peng Dongming ,Dong Qiuli ,Tan Lini ,Jiao Feipeng ,Liu Linqi ,Liu jingyu ,Zhao Chenxi ,Wang Xiaomei
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منبع
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iranian journal of pharmaceutical research - 2013 - دوره : 12 - شماره : 4 - صفحه:581 -586
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چکیده
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In this paper, carbon nanotubes (cnts) were added into chitosan (cs) hydrogels in the form of chitosan modified cnts (cs-cnts) composites to prepare carbon nanotubes hydrogels (cnts-gel). the products, named cs-mwcnts, were characterized by scanning electron microscope (sem) and fourier transform infrared (ftir) spectroscopy. swelling properties and effect of ph on controlled release performance of the two kinds of hydrogels, cnts-gel and pure chitosan hydrogels without cnts (gel), were investigated respectively. the results showed that cnts-gel possess better controlled release performance than gel. the releasing equilibrium time of cnts-gel was longer than that of gel in both ph = w7.4 and ph=1.2 conditions, although the release ratios of the model drug are similar in the same ph buffer solutions. it is found that release kinetics is better fitted ritger-peppas empirical model indicating a fick-diffusion process in ph = 1.2, while in ph = 7.4 it was non-fick diffusion involving surface diffusion and corrosion diffusion processes.
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کلیدواژه
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Chitosan; Drug delivery; Hydrogel; Multi-walled carbon nanotubes; Release kinetics.
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آدرس
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Changsha University, Department of Bioengineering and Environmental Science, China, Central South University, School of Chemistry and Chemical Engineering, China, Hunan University of Chinese Medicine, School of Pharmacy, China, Central South University, School of Chemistry and Chemical Engineering, China, Central South University, School of Chemistry and Chemical Engineering, China, Central South University, School of Chemistry and Chemical Engineering, China, Changsha University, Department of Bioengineering and Environmental Science, China, Changsha University, Department of Bioengineering and Environmental Science, China, Changsha University, Department of Bioengineering and Environmental Science, China, Changsha University, Department of Bioengineering and Environmental Science, China
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Authors
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