synthesis and characterization of a novel zinc-based metal-organic framework containing benzoic acid: a low-toxicity carrier for drug delivery

In recent years, metal-organic frameworks (mofs) have gained attention in the biomedical field, particularly as drug carriers for treating tumors. therefore, we decided to synthesize a novel benzoic acid zn-based mof and study the zn-based mofs' drug-delivery properties and the drug-delivery system's anticancer effects. this study successfully synthesized a zinc-based mof using solvent thermal synthesis. the crystal structure of a zn-based mof was investigated using thermogravimetric analysis, x-ray diffraction, and fourier transform infrared spectroscopy. subsequently, the results of uv spectrophotometry showed that doxorubicin was successfully loaded with a loading amount of 33.74%. furthermore, the drug release experiments demonstrated that the zn-based mof was ph-sensitive, releasing more at a ph of 3.8 than at ph 5.8 or 7.4. finally, the zn-based mof loaded with drugs exhibited high antitumor activity against hepg2 cells while demonstrating remarkably low toxicity to normal cells (lo2). taken together, these results demonstrate that the zn-based mof has the potential to serve as a carrier in the field of drug delivery systems.