solubility of some drugs in aqueous solutions of choline chloride-based deep eutectic solvent systems: experimental data, modeling, and the impact of solution ph

Background: the solubility of drugs in water and organic solvents is a crucial factor in numerous pharmaceutical processes. in recent years, a new type of solvent called deep eutectic solvents (dess) has been developed as a useful solvent for drugs. choline chloride-glycerol/urea (chcl-g/u) systems are dess recognized as a novel category of environmentally friendly solvents. one recent application of this type of des in water is the solubilization of drugs. objectives: this study aimed to investigate the solubility of certain drugs in chcl-g/u. in addition, the solubilization mechanisms of the dess studied, and quantitative structure-property relationship (qspr) models for solubilization were proposed. methods: the solubility of 13 drugs in an aqueous solution of the chcl-g/u system was investigated using the shake flask method. the study was conducted at 10% and 50% mass fractions of the studied systems. multiple linear regression models were used to develop mathematical relationships between the solubilization of the studied compounds in the presence of chcl-g/u + water mixture using qspr models. results: the solubility of the compounds showed a significant increase upon adding chcl-g/u to the aqueous solutions. based on the data obtained, qspr models were developed using solubilization ratio and structural descriptors. conclusions: the experimental data demonstrates the potential of utilizing chcl-g/u as a medium to enhance the solubility of poorly soluble drugs in water. solubilization of solutes in chcl-g/u + water mixtures could be correlated with the structural properties of drugs. moreover, the final ph of the solutions in chcl-u is a critical factor that must be considered when using this system for solubilization.