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synthesis and biological evaluation of new nitroimidazole derivatives as anti-helicobacter pylori agents against metronidazole-resistant strains
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نویسنده
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bayati zahra ,amidi salimeh ,shahabimehr mahnaz ,alebouyeh masoud ,mahboubi arash ,tabatabai abbas
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منبع
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iranian journal of pharmaceutical research - 2023 - دوره : 22 - شماره : 1 - صفحه:1 -8
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چکیده
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Since several helicobacter pyloristrains have become resistant to metronidazole, new nitroimidazole derivatives based on metronidazole were designed and synthesized with different substituents on imidazole nitrogen. the activity of the synthesized compounds was evaluated against 20 clinically isolated metronidazole-resistant h. pyloristrains. some synthesized compounds were effective against those metronidazole-resistant h. pyloristrains. three compounds exhibited the most potent inhibitory activities (mic 50= 8 µg/ml and mic 90= 16 µg/ml).
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کلیدواژه
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nitroimidazole derivatives ,metronidazole resistance ,helicobacter pylori ,synthesis
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آدرس
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shahid beheshti university of medical sciences, school of pharmacy, department of pharmaceutical chemistry, iran, shahid beheshti university of medical sciences, school of pharmacy, department of pharmaceutical chemistry, iran, islamic azad university, tehran branch, faculty of pharmaceutical sciences, department of biology, iran, shahid beheshti university of medical sciences, gastroenterology and liver diseases research center, research institute for gastroenterology and liver disease, iran, shahid beheshti university of medical sciences, food safety research center, school of pharmacy, department of pharmaceutics, iran, shahid beheshti university of medical sciences, school of pharmacy, phytochemistry research center, department of pharmaceutical chemistry, iran
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پست الکترونیکی
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sa_tabatabai@yahoo.com
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Authors
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