Antioxidant Activity and Hemocompatibility Study of QuercetinLoaded Plga Nanoparticles

Quercetin (qu) is an important flavonoid compound presenting lots of biological activities,but its application has been limited due to its low aqueous solubility and instability. in thisstudy, conducted to improve these properties of the quercetin, quercetin-encapsulated plgananoparticles were prepared, characterized, and evaluated for antioxidant and hemolytic activity.nanoparticles were produced by single emulsion solvent evaporation method. four differentprocess parameters initial qu amount, pva concentration, pva volume, and initial plga amountwere investigated to obtain the nanoparticles which have minimum particle size and maximumentrapment efficiency. synthesized nanoparticles were evaluated for particle size, entrapmentefficiency, and reaction yield. additionally, antioxidant properties and in-vitro hemolytic activityof quercetin loaded nanoparticles with different particle size were also evaluated for the firsttime in the literature. the antioxidant activity results showed that nanoparticles have differentantioxidant activity, depending on the amount of quercetin release from nanoparticles at differentparticle sizes. the hemolytic activity results show that all nanoparticles exhibited favorablecompatibility to red blood cells and no significant hemolytic effect was observed.