Preparation, Optimization and Characterization of Chitosancoated Liposomes for Solubility Enhancement of Furosemide:A Model BCS IV Drug

Most of the drugs are administered orally and they must be absorbed from gastrointestinaltract for systemic effect. generally, drug molecules get dissolved in gi fluids before absorption.solubility and permeability of drugs are considered as two parameters in biopharmaceuticalclassification system (bcs). many researches were performed to change permeability andsolubility of the drugs to improve abruption and bioavailability of them. lipidic nanocarrierssuch as nanoliposomes are one approach to dissolve poorly water soluble drugs. furosemide(fmd) as a typical molecule in bcs iv has low solubility and permeability. thermodynamically,molecules of fmd could stay in the space of liposomal membrane. in this study effectiveparameters to preparation of nanoliposomes coated by chitosan (ccls) were screened optimizedby experimental design. particle size, polydispersity index, and surface potential of optimizedccls have 155.8 ± 3.5 nm, 0.229 ± 0.022, and 25.2 ± 3.5 mv, respectively. fmd was loaded inoptimized ccls 98.94 ± 0.7%. size of ccls have verified by atomic force electron microscope.ccls loaded by fmd were dried and in-vitro study was performed to test release of fmd frompowder. results demonstrated that solubility and dissolution of fmd increased by loading inccls in comparison to crystalline fmd and physical mixture of fmd and materials of ccls.