Chemical Composition, Antioxidant, Genotoxique and Antigenotoxic Potentials of Phlomis Bovei De Noé Aerial Parts.

In the present work, chemical investigation of the aerial parts of phlomis bovei de noé anendemic species from algeria, led to the isolation and identification of seven known compoundsincluding five flavones glycosides: chrysoeriol 7-o-(3’’-(e et z)-p-coumaroyl)-β-glucoside (1),terniflorin (apigenin-7-o-(6’’-e-p-coumaroyl)glucoside) (3), apigenin-7-o-(6’’-(5’’’-methoxycoumaryl)glucoside (4), apigenin 7-o-(3″-p-coumaryl)glucoside (5), hispidulin-7-o-glucuronide(6) and two cinnamic acid derivatives: p-coumaric acid methyl ester (e et z) (2), chlorogenic acid(7). compound 4 is described for the first time in the species bovei de noé, the genus phlomis andthe lamiaceae family. structures elucidation was performed by comprehensive 1d and 2d nmranalyses, mass spectrometry and by comparison with literature data. some pure compounds andextracts have been evaluated for their antioxidant activities through different methods: dpphand abts assays as well as cuprac assay. genotoxic and antigenotoxic activities of purecompounds were also evaluated in-vitro on escherichia coli pq37 cells by the sos chromotest.