LED Photo-polymerization, a Novel Strategy for Triggered Release Liposomes

Led light is used for many medical and cosmetic applications such as phototherapy andskin rejuvenation. such physical methods can be combined with drug therapy, such as ledresponsivedrug delivery system, the subject of present investigation.to perform this investigation, a nanoliposome composed of dppc, dspe-peg2000, anddc8,9pc, was prepared as led-sensitive systems. calcein was loaded in the liposomes as afluorescent probe for drug release studies. different led wavelengths (blue, green and red) wereused for triggering release of calcein from nanoliposome. indoor daylight, darkness, and sunlightwere applied as controls.results showed that liposomes do not release their cargo in darkness, but they released it inresponse to indoor daylight, sunlight and leds, with the blue light showing the highest effect.results also showed that release of calcein was sensitive to wavelength.our results reveal potential of led-sensitive liposomes for medical and cosmetic applicationsand that such system can be combined with phototherapy. such concomitant therapies can increasemedical/cosmetic effects and decrease adverse reactions to phototherapy.