CB2 Agonist (AM1241) Improving Effect on Ovalbumin-Induced Asthma in Rats

Asthma is a disease characterized by spontaneous contraction of the airways in response to awide variety of endogenous and exogenous stimuli. many asthma models are used to mimic thehuman asthma model in the literature. in order to better understand the role of the cannabinoid (cb)2 receptor in the ovalbumin (ova)-induced asthma model, a combination of both selective cb2agonist (am1241) and antagonist (am630) was used to improve inflammatory hypersensitivityand edema in rats. in the present study, it was found that ova decreased body weight (p < 0.05),increased lung weights (p < 0.05), increased diastolic and systolic blood pressure (p < 0.001),and caused irregularity in pulmonary functions (p < 0.001). moreover, cb2 agonist was foundnot to reduce body weight, cause blood pressure and respiratory irregularities (p < 0.05). ovaled to increase in ige, tnf-α, il-4, mda level (p < 0.001), and total wbc count (p < .05). cb2treatment caused to reduce the number of total wbc and the level of total protein in balf, tohinder to increase level of mda, ige, tnf-α, and il-4 (p < 0.05) in balf or serum or lungtissue. but cb2-antagonist treatment prevented the protective effect of cb2 agonist. the aim ofthis study was to study the role of the cb2 receptor in the ova induced asthma model, to improveinflammatory hypersensitivity, and edema in the rats. the results suggested that cb2 agonistadministration to ova induced asthmatic rats via anti-asthmatic potential through inhibition ofparameters such as ige, il-4, tnf-α, microvascular escape, and oxidative stress.