synthesis, structural characterization, and cytotoxic activity of new benzo[d]imidazo[2,1-b]thiazole derivatives against mcf-7 breast cancer cells

Breast cancer is an invasive disease with a high prevalence among females. despite various treatments, studies are still ongoing to find an effective treatment for this disease. this study aimed to synthesize a new series of diaryl benzo[d]imidazo[2,1-b]thiazole compounds containing aminoethoxy side chain and in vitro investigate their cytotoxicity on a human breast cancer cell line (mcf-7). twelve derivatives (6a-6l) were synthesized from this scaffold, the structures of which were spectroscopically confirmed. the cytotoxic effects of the derivatives on the mcf-7 cell line were also assessed using the mtt assay. all these compounds showed a good inhibitory effect on the mcf-7 cell line, compared to that of tamoxifen. compounds (6i) and (6j) showed higher cytotoxicity with relevant inhibitory effects of 81% and 73%, respectively.