anti-inflammatory properties of the genus symphytum l.: a review

The symphytum genus has been mainly used in traditional medicine, containing its anti-inflammatory activity. symphytum spp.’s active components, such as allantoin, polyphenols, flavonoids, and alkaloids, can act on several intentions in the signaling pathway, constrain pro-inflammatory enzymes, reducing the construction of inflammatory chemokine’s and cytokines, and decreasing oxidative stress, which afterward suppresses inflammation procedures. preclinical and clinical trials have reported the prevailing anti-inflammatory effect of several symphytum species. this review presents an overview of the anti-inflammatory activities of different products and bioactive constituents in this genus. the papers with the english language were gathered from 2000 to 2021. this review may provide a scientific base for establishing innovative and alternative techniques for isolating a single individual from this genus to attenuate inflammatory disorders. the symphytum genus is waiting for researchers to develop safe and effective anti-inflammatory agents for additional investigation of other different mechanisms of action.