simultaneous determination of multicomponent dosage forms using benchtop nmr spectroscopy: application to phenytoin-phenobarbital combination

The use of nuclear magnetic resonance (nmr) spectroscopy as a tool for determining pharmaceutical molecules in bulk drugs and their dosage forms is growing. new advancements in benchtop nmr spectrometers with cryogen-free magnets have made this technique more appealing and accessible. herein, we developed a method using a benchtop nmr spectrometer to quantify phenytoin (pht) and phenobarbital (phb) in bulk and combined dosage forms. the results were compared to those obtained by high performance liquid chromatography (hplc) as a well-characterized procedure. this method is simple, low cost, relatively fast, and non-inferior to hplc in terms of figures of merit.