|
|
|
|
chitosan/pva/doxycycline film and nanofiber accelerate diabetic wound healing in a rat model
|
|
|
|
|
|
|
|
نویسنده
|
hedayatyanfard keshvad ,bagheri kholenjani shadab ,abdollahifar mohammad amin ,amani davar ,habibi behnam ,zare fatemeh ,asadirad ali ,pouriran ramin ,ziai ali
|
|
منبع
|
iranian journal of pharmaceutical research - 2020 - دوره : 19 - شماره : 4 - صفحه:225 -239
|
|
چکیده
|
In this study, we evaluated the effects of nanofiber and film polymers with doxycycline for treating a wound in a diabetic rat model. 108 male rats were divided into six groups, the control group, the diabetic control, and the groups were diabetic rats receiving different wound dressing. at the 3rd, 7th, and 14th days, macroscopic/histologic imaging and tissue sampling were performed. tissues were analyzed for il-1β, tnf-α, il-10, timp-1, and mmp-2 by using elisa. dressings of chitosan, polyvinyl alcohol, and doxycycline increased the rate of wound closure, the volume of collagen, dermal, and epidermis. in addition, it increased the number of fibroblasts and basal cell epidermis cells, vascular length, and decreased the number of neutrophil cells. inflammatory cytokines and mmp-2 were decreased, and anti-inflammatory il-10 and timp-1 were increased. it was ultimately attained that the combination of chitosan/ polyvinyl alcohol /doxycycline could be a useful dressing for the healing of diabetic wounds.
|
|
کلیدواژه
|
chitosan; doxycycline; film; nanofiber; diabetic wound; polyvinyl alcohol
|
|
آدرس
|
alborz university of medical sciences, school of medicine, cardiovascular research center, department of physiology and pharmacology, iran, amirkabir university of technology, tehran polytechnic, polymer and color engineering department, iran, shahid beheshtiuniversity of medical sciences, school of medicine, department of biology and anatomical sciences, iran, shahid beheshti university of medical sciences, school of medicine, department of immunology, iran, shahid beheshti university of medical sciences, school of medicine, department of pharmacology, iran, shahid beheshti university of medical sciences, school of medicine, department of biology and anatomical sciences, iran, ahvaz jundishapur university of medical sciences, faculty of medicine, department of immunology, iran, shahid beheshti university of medical sciences, school of medicine, department of pharmacology, iran, shahid beheshti university of medical sciences, school of medicine, department of pharmacology, iran
|
|
پست الکترونیکی
|
saziai@gmail.com;aliziai@sbmu.ac.ir
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|