facile synthesis and characterization of ibuprofen-mesoporous hydroxyapatite nanohybrid as a sustained drug delivery system

The present study deals with the fabrication of ibuprofen mesoporous hydroxyapatite (ibumha) particles via the incorporation of ibuprofen (ibu)—as a nonsteroidal antiinflammatory drug—into mesoporous hydroxyapatite nanoparticles (mhanps) using an impregnation process, as a novel drug delivery device. mhanps were synthesized by a self assembly process using cetyltrimethylammonium bromide (ctab) as a cationic surfactant and 1dodecanethiol as a pore expander under basic condition. the focus of the present study was to optimize the incorporation of ibu molecules into mhanps under different loading conditions. the synthesized mhanps and ibumha particles were confirmed by xray diffraction (xrd), fouriertrans form infrared spectroscopy (ftir), brunauer–emmett–teller (bet), transmission electron microscopy (tem), and thermal analysis (tga). drug loading (dl) efficiency of ibumha particles was determined by ultraviolet–visible (uvvis) spectroscopy, and indicated that the optimized ibumha particles with high dl (34.5%) can be obtained at an ibu/ mhanps ratio of 35/50 (mg/mg), impregnation period of 24 h, and temperature of 40 °c using ethanol as solvent. invitro drug release test was carried out to prove the efficiency of ibumha particles as a sustained drug delivery system. a more sustained and controlled drug release was observed for this particles, indicating that it may be have good potential as drug reservoirs for local drug release.