UPLC–ESI-PDA–Ms^n Profiling of Phenolics Involved in Biological Activities of the Medicinal Plant Halocnemum Strobilaceum (Pall.)

Halocnemum strobilaceum is a halophyte present in the humid and arid bioclimatic regions of egypt. the current study aimed at uplc/pda/esi-msn qualitative chemical profiling of the phyto-constituents underlining both antioxidant and cytotoxic activities of the bio-active fraction in comparison with the other fractions. it resulted in detection of several related compounds to prenylated flavonol icariin as a first report in this species. results showed that ethyl acetate exhibits an appreciable antioxidant activity using in-vitro dpph assay with percentage of 82.35% and remarkable anticancer capacity against most common types of cancer in egypt; breast (mcf-7), human prostate (pc-3) cancer cell lines, and human lung carcinoma (a-549) with ic_50 43.1± 2 μg/ml, 115±5 μg/ml, and 53.3±3 μg/ml respectively. these findings point out the appropriate solvent for extraction of the bio-phenolics with this halophyte which is a considerable source of remarkable potential secondary metabolites that exhibit original and interesting anticancer capacity.