New Diterpenoids from the Aerial Parts of Salvia reuterana

The genus salvia is a valuable origin of structurally diverse terpenoids. in a project directed at structurally interesting bioactive metabolites from iranian salvia species, we studied salvia reuterana. two new labdane diterpene, 6β, 14α-dihydroxy-15-acetoxysclareol (1), and 14α, 15- dihydroxy sclareol (2), were isolated from the aerial part of the plant. their structures were established mainly by 1d and 2d nmr spectroscopic techniques, including 1h-1h cosy, hsqc and hmbc methods and hr-esi-tofms spectral data. compound 1 and 2 were tested for their inhibitory activity toward hela and mcf-7 cell lines. our results showed that s. reuterana is a rich source of labdane diterpenoids. these compounds are rather rare in salvia species, although they are frequently found in other genera of the lamiaceae. s. reuterana is a new source of these diterpenoids.