Enhanced Solubility and Bioavailability of Apigenin via Preparation of Solid Dispersions of Mesoporous Silica Nanoparticles

In this study, a novel mesoporous silica nanoparticles drug carrier contributes to improving the solubility, dissolution, and the oral bioavailability of apigenin (ap). the apigenin of solid dispersion of mesoporous silica nanoparticles (ap-msn) was prepared by physical absorption method and also, in-vitro drug release and in-vivo bioavailability performance were evaluated. based on its solubility, the ap-msn solid dispersion was prepared at the weight ratio of 1:1 to obtain the optimum solubility. the loading efficiency (le), encapsulation efficiency (ee), and solubility of ap-msn solid dispersion were 29.71%, 42.27%, and 25.11 μg/ml, respectively. sem, tem, bet, ftir, xrd, dsc, and tg were also carried out. these results demonstrated that ap was good absorbed into the pores of msn through physical absorption effect of msn. the dmf residues of ap-msn solid dispersion meet the ich requirements. it was vital that the ap-msn solid dispersion behaved well in-vitro and the accumulative release of ap-msn solid dispersion was 2.37 times higher than that of raw ap. in-vivo study, the ap area under curve0-t was 8.32 times higher for the ap-msn solid dispersion than that of raw ap, which indicated that the bioavailability of ap-msn solid dispersion was greatly improved. therefore, the prepared ap-msn solid dispersion presents potential as a novel oral therapeutic agent formulation for clinical application.