Synthesis and Biological Evaluation of a Novel Glucosylated Derivative of Gadolinium Diethylenetriaminepentaacetic Acid for Tumor Magnetic Resonance Imaging

Cancer detection in early stage using a powerful and noninvasive tool is of high global interest. in this experiment, a small-molecular-weight glucose based derivative of gd^3+-1-(4-isothiocyanatobenzyl) diethylene tri amine penta acetic acid (gd^3+-p-scn-bn-dtpa-dg) as a novel potential mr imaging contrast agents was synthesized. gd^3+-p-scn-bn-dtpa-dg was synthesized with reacting of glucosamine and 1-(4-isothiocyanatobenzyl) diethylene triamine penta acetic acid then loaded by gadolinium to make novel agent of functional mr imaging. the relaxivity, t_1, t_2 relaxation times, and cell toxicity of this contrast agent were studied. the results demonstrated that the sugar moieties linked to gd^3+-p-scn-bn-dtpa efficiently increase its cellular uptake in normal cells 25% and in cancereous cells upto 67%. the gd^3+- p-scn-bn-dtpa-dg significantly (p < 0.05) decreased mcf-7 tumor cell numbers without any significant toxicity on normal human kidney cells. finally, it displayed an intense signal on t_1 weighted with respect to the unlabeled cells. based on the findings from the present research gd^3+-p-scn-bn-dtpa-dg be a potential breast molecular imaging. however, further investigations by anticancer studies are in the pipeline.