Synthesis, Computational Studies and Anticonvulsant Activity of Novel Benzothiazole Coupled Sulfonamide Derivatives

We report herein the synthesis of ¾ substituted benzene sulfonamides linked via phenyl ring to a benzothiazole moiety. the title compounds in the two series namely n-(4-(benzothiazole-2-yl) phenyl) 4- substituted benzene sulfonamides and n-(4-(benzothiazole-2-yl) phenyl) 3- substituted benzene sulfonamides were synthesized by condensing 2-(3/4-aminophenyl) benzothiazole with various substituted sulfonyl chlorides. the synthesized compounds were subjected to neurotoxicity screening, computational studies, and evaluation of their anticonvulsant potential. amongst all the synthesized compounds, compound 9 emerged as the most potent anticonvulsant agent in maximal electroshock (mes) model (standard: phenytoin) in mice and showed three hydrogen bond interactions with the nicotinic acetylcholine ion gated receptors (pdb id: 2bg9). interestingly, compound 13 showed five hydrogen bond interactions with the target protein and thus excellent binding affinity upon computational analysis but was found to be neurotoxic.