Effect of Combination Therapy of Methotrexate with Vitamin A in Patients with Low Risk GTN (Gestational Trophoblastic Neoplasia)

Methotrexate as a single agent chemotherapy in most women with low risk gestational trophoblastic neoplasia (gtn) has been associated with high treatment rate. combination of methotrexate with vitamin a due to reduced number of chemotherapy regime courses is one of the treatment options for patients with low-risk gtn. therefore, this study was performed with aim to determine the efficacy of combination therapy of methotrexate with vitamin a in low risk gtn treatment. this randomized clinical trial was performed on 49 patients with low risk gestational trophoblastic neoplasia. the treatment group (group a = 19 cases) weekly received methotrexate 50 mg/m2, and vitamin a 200000 iu, intra-muscular, and the control group (group b = 30 cases) only received methotrexate 50 mg/m2 weekly. all patients were followed up for 8 weeks. then, treatment outcomes were compared between two groups, and response to therapy was assessed in two groups by evaluation of hcg serum level. p < 0.05 was considered significant.mean of b-hcg serum level after 4 weeks in group a and group b was 68.5 miu/ml and 360 miu/ml, respectively (p = 0.018), and after 8 weeks was 1 miu/ml and 12 miu/ml, respectively (p = 0.074). combination therapy of methotrexate and vitamin ain low risk gtn is associated with shorter duration of chemotherapy.