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Determination of Enrofloxacin and Ciprofloxacin Residues in Five Different Kinds of Chicken Tissues by Dispersive Liquid–Liquid Micro extraction Coupled with HPLC
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نویسنده
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rezaee moghadam najmeh ,arefhosseini rafie ,javadi afshin ,lotfipur farzaneh ,ansarin masood ,tamizi elnaz ,nemati mahboob
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منبع
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iranian journal of pharmaceutical research - 2018 - دوره : 17 - شماره : 4 - صفحه:1182 -1190
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چکیده
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Contamination of food producing animals by veterinary drug residues, particularly quinolones, is an essential issue in food safety that causes increasing concern in consumers.the aim of this study was to investigate the occurrence of enrofloxacin and its main metabolite,ciprofloxacin, in chicken tissue samples slaughtered in tabriz, iran. totally 250 samples including liver, muscle, gizzard, heart, and skin were studied. dispersive liquid-liquid microextraction technique (dllme) was used as a simple, high performance, low-cost, and fast sample pretreatment method followed by a high-performance liquid chromatography with uv detection for quantitative analysis. the residues of enrofloxacin were detected and quantified in 26 liver(52%) and 10 skin (20%) samples and ciprofloxacin residues were detected in 3 skin (6%)samples and accurately determined in 15 liver (30%) samples; however they were not detected in gizzard, heart, and muscle samples. the results showed the accumulation of enrofloxacin and ciprofloxacin residues in chicken liver and skin.
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کلیدواژه
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Enrofloxacin; Ciprofloxacin; Dispersive liquid–liquid microextraction(DLLME); HPLC; Chicken.
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آدرس
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tabriz university of medical sciences, drug applied research center, Iran. tabriz university of medical sciences, faculty of nutrition and food sciences, department of biochemistry and diet therapy, iran, tabriz university of medical sciences, faculty of nutrition and food sciences, department of biochemistry and diet therapy, Iran, tabriz university of medical sciences, food and drug safety research center, health management and safety promotion research institute, Iran. azad islamic university, tabriz branch, faculty of veterinary medicine, department of food hygine, Iran, tabriz university of medical sciences, faculty of pharmacy, department. of pharmaceutical and food control, Iran, tabriz university of medical sciences, drug applied research center, Iran, tabriz university of medical sciences, food and drug safety research center, health management and safety promotion research institute, Iran. tabriz university of medical sciences, faculty of pharmacy, department. of pharmaceutical and food control, iran, tabriz university of medical sciences, food and drug safety research center, health management and safety promotion research institute, Iran. tabriz university of medical sciences, faculty of pharmacy, department. of pharmaceutical and food control, iran
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پست الکترونیکی
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nematim@tbzmed.ac.ir
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Authors
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