Efficient Synthesis and Antimicrobial Evaluation of Pyrazolopyranopyrimidines in the Presence of SBA-Pr-SO3H as a Nanoporous Acid Catalyst

A simple, efficient, and environmentally friendly method has been developed for the synthesis of a series of tricyclic fused pyrazolopyranopyrimidines via a one-pot three-component reaction of barbituric acids, aromatic aldehydes, and 3-methyl-5-pyrazolone in the presence of sba-pr-so_3h. sba-15 mesoporous silica material functionalized with propyl sulfonic acid groups was used as a heterogeneous bronsted acid catalyst with hexagonal structure, high surface area, thick walls, and large uniform pores. all reactions were performed under reflux conditions in water in the presence of a catalytic amount of sba-pr-so_3h. high yields, mild reaction conditions, short reaction times, and simple work-up procedures are some advantages of this method. the antimicrobial activities of the synthesized compounds were also evaluated and some products exhibited significant antibacterial activities at low concentrations.