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Antiparasitic Activity and Essential Oil Chemical Analysis of the Piper Tuberculatum Jacq Fruit
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نویسنده
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منبع
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iranian journal of pharmaceutical research - 2018 - دوره : 17 - شماره : 1 - صفحه:268 -275
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چکیده
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With the increase of neglected diseases such as leishmaniasis and chagas disease, there was a need for the search for new therapeutic alternatives that reduce the harm caused by medicine available for treatment. thus, this study was performed to investigate the antiparasitic activity of the essential oil from the fruits of piper tuberculatum jacq, against lines of leishmania braziliensis (mhom/co/88/ua301), leishmania infantum (mhom/es/92/bcn83) and trypanosoma cruzi (lc-b5 clone). before running protocols, an analysis of the chemical composition of essential oil was conducted, which presented monoterpenes and sesquiterpenes. as major constituents, ß-pinene and α-pinene were identified. regarding to antiparasitic activity, the essential oil had an ec_50 values of 133.97 µg/ml and 143.59 µg/ml against variations promastigotes of l. infantum and l. braziliensis, respectively. as for trypanocidal activity, theoil showed ec_50 value of 140.31 µg/ml against epimastigote form of t. cruzi. moreover, it showed moderate cytotoxicity in fibroblasts with lc_50 value of 204.71 µg/ml. the observed effect may be related to the presence of terpenes contained in the essential oil, since it has its antiparasitic activity proven in the literature.
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کلیدواژه
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Antiparasitic activity; Piper tuberculatum Jacq; Essential oil; Terpenes; Natural products.
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آدرس
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regional university of cariri, department of biological chemistry, Brazil, regional university of cariri, department of biological chemistry, Brazil, regional university of cariri, department of biological chemistry, Brazil, regional university of cariri, department of biological chemistry, Brazil, regional university of cariri, department of biological chemistry, Brazil, regional university of cariri, department of biological chemistry, Brazil, regional university of cariri, department of biological chemistry, Brazil, regional university of cariri, department of biological chemistry, Brazil, regional university of cariri, department of biological chemistry, Brazil, regional university of cariri, department of biological chemistry, Brazil, regional university of cariri, department of biological chemistry, Brazil, foundation moisés bertoni, center for the development of scientific research, laboratories diaz gill, Paraguay, foundation moisés bertoni, center for the development of scientific research, laboratories diaz gill, Paraguay, regional university of cariri, department of biological chemistry, Brazil, regional university of cariri, department of biological chemistry, Brazil, federal university of paraíba, department of molecular biology, Brazil, regional university of cariri, department of biological chemistry, Brazil, regional university of cariri, department of biological chemistry, Brazil
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پست الکترونیکی
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martareginakerntopfm@outlook.com
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Authors
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