Diuretic Potential of Whole Plant Extracts of Pergularia daemia (Forsk.)

The whole plant, pergularia daemia (family: asclepediaceae), was extracted with 50% alcohol and a fresh batch of the plant material was successively extracted with petroleum ether, ethyl acetate and n-butanol to determine its diuretic activity. the diuretic activity of the different extracts at a dose of 400 mg/kg was assessed orally in rats with furosemide as a standard drug using lipschitzs test. all extracts except the petroleum ether extract showed significant increase (p < 0.001) in urine output. urinary electrolyte excretion was also affected by the extracts: the alcoholic, ethyl acetate and n-butanol extract caused an increase in the urinary excretion of sodium and potassium ions. these findings suggest that among the mentioned extracts, ethanolic has the maximum diuretic activity followed by n-butanol extract