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Synthesis and Antimycobacterial Activity of 2-(Phenylthio) benzoylarylhydrazone Derivatives
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نویسنده
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Almasirad Ali ,Samiee-Sadr Somayeh ,Shafiee Abbas
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منبع
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iranian journal of pharmaceutical research - 2011 - دوره : 10 - شماره : 4 - صفحه:727 -731
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چکیده
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A series of new 2-(phenylthio) benzoylaryl hydrazones were synthesized by acid-catalyzed condensation of hydrazide 3 with corresponding aldehydes. the chemical structures of the compounds were elucidated by ft-ir, 1h-nmr and mass spectra. all newly synthesized compounds were evaluated for their antimycobacterial activities against mycobacterium tuberculosis h37rv using the microplate alamar blue assay (maba). compounds 4f (5-nitro-2-furyl analogue) and 4g (5-nitro-2-thienyl analogue) showed antimycobacterial activity with ic90, 7.57 and 2.96 µg/ml, respectively
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کلیدواژه
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Hydrazones; Antimycobacterial activity; Mycobacterium tuberculosis; 5-Nitrofuran; 5-Nitrothiophen
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آدرس
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islamic azad university, Facalty of Pharmacy, Department of Medicinal Chemistry, ایران, islamic azad university, Facalty of Pharmacy, Department of Medicinal Chemistry, ایران, Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Department of Medicinal Chemistry, ایران
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پست الکترونیکی
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almasial@sina.tums.ac.ir
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Authors
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