Chiral Separation of Basic and Zwitterionic Drugs byHighly Sulfated Cyclodextrins Using Short-EndInjection Capillary Electrophoresis

Due to high resolution power of sulfated cyclodextrins (hs-cds), utilization of these selectors for chiral resolution of 7 basic and 2 zwitterionic drugs have been examined. experiments were performed on a hp3dce instrument equipped with an on-column diode array uv absorbance detector. fused silica capillaries with an inner diameter of 50 μm, an outer diameter of 365 μm, and a total length of 45.5 cm (8.5 cm to the detector) were used. capillaries were rinsed with peo once daily. to reduce analysis time, short-end injection technique was applied. the electrophoretic conditions for the stereoselective analysis of drugs were in the carrier mode with 25 mm sodium phosphate buffer containing 1.25% w/v of each hs-cd at ph 2.5 with an applied voltage of +15 kv. at these conditions, rapid enantioresolution(≤3.9 min) of all drugs were achieved.