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Synthesis and Determination of Chronic and Acute Thermal and Chemical Pain Activities of a New Derivative of Phencyclidine in Rats
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نویسنده
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Ahmadi Abbas ,Khalili Mohsen ,Hajikhani Ramin ,Barghi Leila ,Mihandoust Farnaz
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منبع
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iranian journal of pharmaceutical research - 2010 - دوره : 9 - شماره : 4 - صفحه:379 -385
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چکیده
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Phencyclidine (1-(1-phenylcyclohexyl) piperidine, pcp, i) and ketamine (2-o-chlorophenyl-2-methylaminocyclohexan, ii) have shown analgesic effects. some of its derivatives were synthesized and their biological properties have been studied. in this study, a new derivative of pcp, (1-[1-(3-methoxyphenyl) (tetralyl)] piperidine, pcp-och3-tetralyl, iii) was synthesized and the acute thermal pain of this compound was determined using tail immersion test on rats and the results were compared with ketamine and pcp.the results indicated a marked anti-nociception 2-25 min after ketamine injection, but the analgesic effect remained for 40 min following pcp-och3-tetralyl application in tail immersion test. however, the data obtained from formalin test showed that the chronic anti-nociception effect of ketamine was higher than pcp and pcp-och3-tetralyl exhibited almost similar analgesic effect.
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کلیدواژه
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Phencyclidine; Ketamine ,1-Tetralone derivatives; Tail immersion test; Formalin test; Acute and chronic pain
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آدرس
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islamic azad university, Faculty of Sciences, Department of Chemistry, ایران, shahed university, School of Medicine, Department of Physiology, ایران, islamic azad university, Faculty of Science, Department of Chemistry, ایران, islamic azad university, Faculty of Science, Department of Chemistry, ایران, islamic azad university, Faculty of Science, Department of Chemistry, ایران
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پست الکترونیکی
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abbas_ahmady_3957@yahoo.com
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Authors
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