Evaluation of Analgesic Potential of Solanum trilobatum Roots

In the present work, the antinociceptive action was assayed in several experimental models in mice: writhing, formalin and hot plate tests. the crude alkaloid fraction (25, 50, 100 mg/kg) and in a dose-dependent manner significantly reduced the nociception by acetic acid intraperitoneal injection (p < 0.001). in the formalin test, the extract (50 and 100 mg/kg) also significantly reduced the painful stimulus in both phases of the test (p<0.001). treatment with the extract (25, 50, 100 mg/kg) when given i.p. or pentazocine (5 mg/kg, s.c.) produced a significant increase of the reaction time in hot plate test. these result showed that the alkaloid extract of solanum trilobatum contains active analgesic principles acting both centrally and peripherally.