assessing the optimal dose of mivacurium for modified rapid sequence intubation in emergency surgical settings: a randomized, double-blind trial

Background: modified rapid sequence intubation (rsi) is crucial in emergency surgery, particularly for patients with a full stomach, as it allows for the administration of general anesthesia (ga). objectives: this work aimed to evaluate mivacurium effectiveness and optimal dose in modified rsi. methods: this randomized double-blind study involved 100 patients, aged between 20 - 60 years, of both sexes, with the american society of anesthesiologists physical status classification of i - iii, who were undergoing emergency surgery under ga. patients were randomized into two equal groups and received mivacurium in a dose of 0.3 mg/kg in group m1 or 0.4 mg/kg in group muscarinic-2 (m2). results: intubating conditions were significantly better in group m2 than in group m1. the onset of adequate muscle relaxation was significantly earlier in group m2 than in group m1 (p < 0.001). at the third minute, mean arterial blood pressure recordings were significantly lower in group m2 (p = 0.04) than in group m1. the recovery time was significantly longer in group m2 than in group m1 (p < 0.001). conclusions: mivacurium in a 0.4 mg/kg dose resulted in more favorable intubating conditions during rsi and a more profound, earlier onset of muscle relaxation, but with a longer recovery time compared to the 0.3 mg/kg dose.