Does Kidney Transplantation With Deceased or Living Donor Affect Graft Survival?

Background: there are growing numbers of patients with end-stage renal disease globally at an unexpected rate. today, the most serious challenge in transplantation is organ shortage; hence, using deceased donor is increasingly encouraged.objectives: the aim of the study was to investigate the differences in survival rates between kidney transplant recipients with deceased donor and living donor.patients and methods: in a retrospective cohort study, 218 patients who had undergone kidney transplantation in our institute from april 2008 to september 2010 were recruited. demographics and post-transplantation follow-up data including immunosuppression regimens, rejection episodes, and survival rates were evaluated. the patients were assigned to two groups according to the donor kidney transplantation: group i, living donor kidney transplants; and group ii, deceased donor kidney transplants.results: although there were no significant differences in one-year survival rates of patient and graft between study groups, three-years survival rates of patient and graft were significantly longer in living donor kidney transplants in comparison with the deceased donor kidney recipients (p = 0.006 and p = 0.004, respectively). in cox-regression model after adjusting for other confounding factors such as age, sex, diabetes mellitus, and first- or second-time transplantation, overall patient and graft survivals were also significantly shorter in deceased kidney transplantation than those who received kidney from a living donor (hr, 3.5; 95% ci, 1.2-10.4; and p = 0.02 for patient survival; and hr, 5.4; 95% ci, 1.5-19.5; and p = 0.009 for graft survival).conclusions: we found acceptable short-term survival in both groups; however, living donor recipients continue to have better long-term patient and graft survival rates.