Splenic Marginal Zone Lymphoma and Concurrent Membranoproliferative Glomerulonephritis With IgMKappa Deposits in a HCV-Seropositive Patient

We report a case of membranoproliferative glomerulonephritis (mpgn) with igmκ light chain deposits in a patient with chronic hepatitis c infection and simultaneous onset of monoclonal igmκ gammopathy with concurrent small b-cell lymphoproliferative disease. the patient presented with hepatosplenomegaly and a uremic state that necessitated dialysis without any clinical signs of systemic disease apart from the chronic infection with hepatitis c virus. the diagnostic approach led to a renal biopsy that revealed mpgn with dominant igmκ deposits and interstitium infiltration by the lymphoid cells. the bone marrow biopsy findings were consistent with splenic marginal zone lymphoma, a rare lymphoproliferative disorder with a rare association with mpgn. our case indicates high diagnostic value of renal biopsy for rare lymphoplasmacytic neoplasms with renal dysfunction as their predominant clinical manifestation.